Sexual Desire

Viagra for Women: Flibanserin (Addyi), Where to Buy Online

Flibanserin: if you want to take this medication, you should know about it as much as possible. Let's sort out what you should be aware of before starting to use Flibanserin.

Flibanserin: Comprehensive Overview

Flibanserin is the first medication that is approved by the U.S. Food and Drug Administration. This drug is intended to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. This careful overview will highlight the indications, administration, and potential side effects of the Flibanserin medicine.

Note that you should consult a healthcare professional before beginning to take Flibanserin or any other drug.

Flibanserin Indications

Sexual dysfunction has been reported in nearly fifty percent of women in the United States. Among various reasons for sexual dysfunction in women, hypoactive sexual desire disorder (HSDD) is the most usually identified reason.

Hypoactive sexual desire disorder is determined by limited or absent sexual fantasy and desire which leads to interpersonal strain or increased distress.

The U.S. Food and Drug Administration approved Flibanserin as the first medication destined to treat HSDD in premenopausal women in 2015.

Flibanserin was originally developed for the treatment of depression. However, studies demonstrated that it was not effective in comparison to placebo.

Nevertheless, positive results on sexual function were seen in these initial studies. After that, the effectiveness of the Flibanserin drug has been analyzed through a few clinical trials, three of which had taken part by premenopausal women who had HSDD for not less than six months.

Flibanserin Administration

It is worth mentioning that you should see your doctor who will prescribe a recommended dosage and specify the administration of Flibanserin for you.

However, according to https://europepmc.org/article/MED/29066935, Flibanserin may be administered as a once-daily 100 mg oral tablet taken at bedtime.

It is not advisable to take this medication in the morning. Flibanserin should be taken at bedtime to decrease the risk of syncope, central nervous system depression, hypotension, or accidental injury that may come up in waking hours. Speaking about missed doses, it is advisable to take your dose the next night. It is important not to double the dosage.

If you adhere to the treatment regimen with the Flibanserin medication for eight weeks and inform no improvement in your symptoms, drug intake should be discontinued.

Main Contraindications

Since Flibanserin is associated with the increased risk of hypotension and syncope, this medication is contraindicated to be taken in combination with alcohol and by individuals with hepatic impairment.

Drugs that are not contraindicated but should be taken carefully in combination with Flibanserin are weak CYP3A4 inhibitors, strong CYP2C19 inhibitors, digoxin, other central nervous system depressants, and CYP3A4 inducers.

Strong CYP3A4 inducer medications should not influence the drug's security but may decrease effectiveness because of the increased metabolism of Flibanserin.

In addition, the Flibanserin medicine is contraindicated in pregnancy and breastfeeding. The major reason is that medication effects are not known in these populations.

Potential Side Effects

The most often reported side effects of the Flibanserin medication have a frequency of more than 2%.

These adverse effects are as follows: dizziness, nausea, insomnia, somnolence, fatigue, dry mouth, and others. Hypotension and syncope may come up if patients take Flibanserin with moderate or strong CYP3A4 inhibitors, experience hepatic impairment, or combine the drug's intake with alcohol or other medicine that is known to cause hypotension and syncope.

Central nervous system depression, hypotension, and syncope may likewise come up if you take the Flibanserin medication in the daytime. That's why nighttime administration is advisable.

Other less widespread stated side effects in clinical trials are anxiety, abdominal pain, accidental injury, vertigo, constipation, sedation, appendicitis, and others.

Toxicity

Some animal studies have shown that female rats developed mammary tumors under the influence of Flibanserin within two years and at doses exceeding recommendations by 3 to 10 times. Regarding human studies, clinical relevance has not been determined. However, it has been included in package labeling as a warning.

Taking into account the narrow therapeutic window of the Flibanserin medication, it is not advisable for individuals to exceed the daily dosage of 100mg.

It has been determined that doses that exceed 250 mg may be intolerable and greatly aggravate the above-discussed effects. Nowadays, antidotes to eliminate the effects of Flibanserin toxicity don't exist.

Also, pieces of research have not been carried out on pregnant women to define if there are any associated risks that are connected with maternal or fetal toxicity.

Nevertheless, when animal studies were carried out, it was determined that fetal toxicity, in particular, anatomical abnormalities, sedation, and limited weight gain came up. Animal studies likewise showed that the incidence of fetal loss was increased at doses 15 times greater than pharmacological doses in humans.

The bottom line

To conclude we can say that Flibanserin is a relatively safe medication that is approved as a way of treating hypoactive sexual desire disorder in premenopausal women.

Although this drug has shown some effectiveness in clinical trials, it is crucial for patients to have realistic expectations and contact their doctors to define if Flibanserin is a suitable treatment method for them. As with any medication, Flibanserin has potential side effects. That's why it should be taken under the supervision of your doctor.

It is significant for patients considering the Flibanserin drug to have a careful discussion with their healthcare professionals, weigh the potential advantages and risks, and comprehend the limitations and concrete indications of the medication.

Doctors may evaluate whether Flibanserin is the ideal treatment option for you based on your medical history and concrete needs.

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