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Cialis (Tadalafil)

Cialis is often compared to Viagra. Both name-brand drugs offer help with treating erectile dysfunction, also called ED. There are many cheaper, generic drugs that you can find that do the same thing.

In particular, Cialis is FDA-approved to treat Erectile Dysfunction (ED) in men. That means, this drug helps those who can’t get an erection naturally. Additionally, Cialis is often prescribed to those who suffer from benign prostatic hyperplasia, a prostate condition. There are several different dosages that your doctor might recommend to you.

Overall, there’s quite a lot of information you should know about this drug before you start taking it. Everything is in this article, so be sure to stick around.

What is Cialis?

Cialis is an ED treatment that comes in different strength tablets that you take orally. The strengths include: 2.5 mg, 5 mg, 10 mg, and 20 mg. Your doctor will determine the dosage for you, depending on what you’re treating and your condition.

Cialis contains the main ingredient tadalafil, which is a PDE5 inhibitor (just like the generic version of Viagra - sildenafil). You’ll need to take the drug either daily or an hour before sexual activity, depending on what you’re attempting to treat.

Who is It for?

Cialis (Tadalafil) is for men suffering from ED. The drug uses PDE5 inhibitors to relax the blood vessels in and around the penis. Because of this, men struggling with ED can still experience erections, since the drug allows blood to flow there.

However, it can also be prescribed to those who have Benign Prostatic Hyperplasia (BPH). The medicine causes the bladder to relax, making it easier for you to go to the bathroom.

This drug is for men who can’t naturally experience an erection. If you plan on having sex with ED, this prescription is likely to be essential to you. It can be pricey in the United States, meaning you’ll want to consider a prescription with us instead.

Cialis is not intended for women to use. The drug is generally not tested on women. While there are likely some benefits and similarities to when a man takes it, there are possibly many more side effects as well. It’s best not to take it and instead look into options.

Is Cialis for Me?

Cialis, and generic equivalents, are perfect for men suffering from ED or BPH. The drug is known to assist with the condition, offering a temporary treatment. It’s not recommended for those with heart irregularities, as it can worsen the issues.

The drug also isn’t good for those with blood pressure problems. You’ll want to speak with your doctor before buying if you suffer from high or low blood pressure. The drug could have harmful side effects if you have these health problems.

Overall, Cialis works well for men over the age of 18 who are generally healthy. It’s also good for combating some other health problems, on top of ED. You’ll need to have a prescription for this drug, so make sure to discuss it with your primary health physician first.

Pharmacodynamics and pharmacokinetics

The main active component of Cialis tablets, tadalafil, improves erectile function of the penis by increasing blood flow into the corpora cavernosa. This occurs due to the inhibition of the enzyme phosphodiesterase 5, which in turn leads to the accumulation of nitric oxide in the cavernous bodies.

Nitric oxide stimulates the accumulation of cyclic guanine triphosphate (cGMP), which reduces the tone of the walls of the vascular bed, expands their lumen, and also dilates arterial vessels, helping to increase blood flow to the cavernous bodies of the penis with improved erection.

After taking the Cialis tablet orally, the active ingredient tadalafil is quickly and almost completely absorbed into the blood from the lumen of the small intestine. It reaches its maximum concentration in the blood after 2 hours.

Tadalafil is evenly distributed in tissues and enters the cavernous bodies, where it has a therapeutic effect. It is metabolized in the liver to form inactive breakdown products, which are excreted from the body mainly in feces and, to a lesser extent, in urine.

After taking Cialis tablets, the therapeutic effect develops within 15-20 minutes and can last up to 36 hours.

Indications for use

The main medical indication for taking Cialis tablets is to improve the erectile function of the penis in men, the disruption of which was caused by various reasons.

Contraindications for use

Taking Cialis tablets is contraindicated in case of hypersensitivity of the patient's body to any of the components of the drug, in children under 18 years of age, as well as when taking medications from pharmacological groups containing organic nitrates together.

Directions for use and dosage

Cialis tablets are intended for oral administration. They are taken whole, not chewed, and washed down with a sufficient amount of water at least 16 minutes before the intended sexual contact, regardless of the preliminary meal.

The average recommended therapeutic dosage of the drug is 20 mg. Taking pills is not allowed more than once a day. Improvement in erection and a man's ability to have full sexual intercourse lasts on average for 36 hours after taking Cialis tablets.

Side effects

While taking Cialis tablets, negative pathological reactions can often develop in the form of headache, dyspepsia with nausea and bloating.

Somewhat less frequently, pain in the back and muscles (myalgia), nasal congestion, and a feeling of a rush of heat in the face appear. Very rarely, swelling of the eyelids, redness (hyperemia) of the conjunctiva of the eyes, and periodic dizziness may develop.

If negative pathological reactions occur after taking Cialis tablets, their use should be stopped, and contact a medical specialist.

Special instructions

Before you start using Cialis tablets, it is important to read the instructions carefully. There are several special recommendations regarding their use that are worth paying attention to, including:

  • The use of the drug in men with concomitant renal failure is possible only according to strict medical indications and under medical supervision.
  • In case of moderate and mild renal failure, while taking Cialis tablets, undesirable pathological reactions, in particular back pain, develop much more often.
  • The use of the drug is not recommended for men with cardiovascular pathology (severe atherosclerosis, coronary heart disease, previous myocardial infarction or cerebral stroke, hypertension) since sexual activity is contraindicated for them.
  • The drug is used with caution in men with a predisposition to priapism (prolonged erection of the penis, which is usually accompanied by severe pain), in particular with sickle cell anemia, multiple myeloma, leukemia.
  • Cialis tablets should be used with caution in men with anatomical deformation of the penis (Peyronie's disease, angulation, cavernous fibrosis).
  • A man must be informed that if he has an erection that lasts more than 4 hours, he must consult a doctor.
  • The simultaneous use of the drug with other drugs for the treatment of erectile dysfunction is not recommended.
  • When taking Cialis tablets simultaneously with antacids (drugs that reduce the acidity of gastric juice) and intestinal sorbents, the rate and completeness of absorption of the main active ingredient decreases.
  • It is not recommended to take the drug simultaneously with drugs that are metabolized in the liver, in particular with some antiviral drugs, such as itraconazole, erythromycin.
  • The drug is not intended for use by women.
  • It is not recommended to perform work while taking the drug, which requires sufficient concentration of attention and speed of psychomotor reactions.
  • In the pharmacy chain, Cialis tablets are sold by prescription, so their independent use without appropriate medical prescription is not recommended.

Overdose

If you take Cialis tablets in a dosage that significantly exceeds the therapeutic dose, a more frequent development of adverse pathological reactions is possible. In such cases, symptomatic therapy, which is prescribed by a doctor, is carried out.